August 2017 in Formulating. Diethylene Glycol Monoethyl Ether is also used a solubilizer in drilling and cutting coolants. 2009;10(4):221-7. doi: 10.2165/00128071-200910040-00002. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Transcutol® (Diethylene Glycol Monoethyl Ether): A Potential Penetration Enhancer. Keep away from sources of ignition. An evaluation of dapsone gel 5% in the treatment of acne vulgaris. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Glycol ethers Last updated September 26, 2020. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Ethoxydiglycol, also known as diethylene glycol monoethyl ether or DEGEE, is produced by the ethoxylation of ethanol. Use: Eastman™ DE Solvent (Diethylene Glycol Monoethyl Ether) is a very polar, slow evaporating, water miscible solvent with a low odor. Transcutol® (Diethylene glycol monoethyl ether, DEGEE), CAS # 111-90-0, is commonly used as a vehicle in the formulation or manufacturing process of pharmaceuticals, cosmetics, and food additives. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. A second opinion (SCCP/1200/08) on Diethylene glycol monoethyl ether (DEGEE) for its use as solvent in hair dye formulations was adopted on 16 December 2008 with the conclusion that: "The SCCP is of the opinion that the use of diethylene glycol monoethyl ether (DEGEE) as a Rahim et al. * Used as a solvent and carrier in skin care products * Also known as Diethylene Glycol Monoethyl Ether Functions: According to RealSelf.com, Ethoxydiglycol is a clear, practically colorless, liquids used in cosmetics and personal care products.It is a solvent used to thin out products and decrease viscosity. 5.0 (1) "Customer service" "Great company" Contact Supplier. Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. Diethylenglycolmonoethylether ist eine farblose Flüssigkeit mit süß-muffig bis fruchtigem Geruch. Moreno E, Calvo A, Schwartz J, Navarro-Blasco I, González-Peñas E, Sanmartín C, Irache JM, Espuelas S. Pharmaceutics. Pharmaceutics. It is supplied as a urethane grade solvent. It is a solvent for dyes, nitrocellulose, paints, inks, and resins. Would you like email updates of new search results? Please check your email for instructions on resetting your password. Pharmaceutical Development and Technology. This paper presents unpublished nonclinical safety data using a form of DEGEE which includes a significantly decreased level of impurities, specifically ethylene glycol and diethylene glycol. Learn more. Conclusions: Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. The microemulsion prepared … and you may need to create a new Wiley Online Library account. 2-(2-Ethoxyethoxy)ethanol, also known under many trade names, is the organic compound with the formula CH 3 CH 2 OCH 2 CH 2 OCH 2 CH 2 OH. Product Description: Eastman DE Acetate (diethylene glycol monoethyl ether acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. Diethylene glycol monoethyl ether (DEGEE) is produced via the O-alkylation of ethanol with two ethylene oxide units, followed by distillation. Number of times cited according to CrossRef: Microemulsion composed of combination of skin beneficial oils as vehicle: Development of resveratrol-loaded microemulsion based formulations for skin care applications. ETHOXYDIGLYCOL ETHOXYDIGLYCOL is classified as : Humectant; Solvent; Perfuming; CAS Number: 111-90-0 EINECS/ELINCS No: 203-919-7 COSING REF No: 33802 Chem/IUPAC Name: 2-(2-Ethoxyethoxy)ethanol; Carbitol; Diethylene glycol monoethyl ether; … Due to the unavailability of detailed toxicological studies on DEGEE, the Scientific Committee on Consumer Products (SCCP) found its toxicological reports to be unsatisfactory, comprising only summaries. Es werden mehr als 1000 Tonnen pro Jahr hergestellt. Ethyl Diglycol is used in the production & formulation of pesticides & wood preservaties. Concern Eastman™ DE Acetate (Diethylene Glycol Monoethyl Ether Acetate) is a colorless liquid, soluble in water and miscible in most organic solvents. For certain drug actives, this solvent provides for an intracutaneous depot. HHS Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne.  |   |  Working off-campus? Am J Clin Dermatol. The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne. Formulation and evaluation of self-nanoemulsifying drug delivery system of brigatinib: Improvement of solubility, in vitro release, ex-vivo permeation and anticancer activity. Tagged: odor; glycol ethers; Comments. A literature search was conducted from the year prior to the OECD SIAM Footnote 22 (i.e., October 2004 to April 2016), and no health effects studies that would result in critical effect levels lower than those identified by OECD (2007) were identified. Results Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. This safe, well-tolerated solvent is already used in many cosmetics and will become an ingredient in an increasing number of prescription products. Eigenschaften. diethylene glycol monoethyl ether was done by a member state (France). It is anticipated that this common cosmetic ingredient will be a component in numerous future prescription topical products approved for the US market. Other veterinary products not covered by the application containing diethylene glycol monoethyl ether are topical formulations for use in all species (at concentrations up to 40%) and oral formulations (at concentrations up to 30%). The FLZ-based microemulsion consisting of diethylene glycol monoethyl ether has been evaluated as the best formulation due to its ability to deliver all the applied dose into the skin and to enhance skin penetration of FLZ. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. Topical Corticosteroid Therapy for Psoriasis-A Review of Clobetasol Propionate 0.025% Cream and the Clinical Relevance of Penetration Modification. Diethylene glycol monoethyl ether when used in a 99.9+% pure pharmaceutical grade is safe and well tolerated. The purpose of this document is to reassess the exemptions from the requirement of a tolerance for residues of these chemicals when used as inert ingredients in pesticide formulations as required under the Food Quality Protection Act (FQPA). Glycol ethers are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Aims To provide dermatologists a review of this solvent’s safety and tolerance in addition to describing how it interacts with the stratum corneum, sebum, and resident microflora. 1) is a colorless liquid with a molecular weight of 137.17 g/mol and a density of 0.989 g/mL. The effects of polar excipients transcutol and dexpanthenol on molecular mobility, permeability, and electrical impedance of the skin barrier. ) extract using self-nanoemulsifying formulation Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. The solvents diethylene glycol monomethyl ether, diethylene glycol monoethyl ether and diethylene glycol mono-n-butyl ether serve as diluents in hydraulic brake fluids. It is an excipient used as a solubilising agent and an absorption enhancer. It is used primarily as a coalescing aid in latex paints and as a solvent in printing inks. Journal of Drug Delivery Science and Technology. It is an active solvent for cellulose acetate butyrate, nitrocellulose, epoxy resins, and other coating materials. Up to half of the applied solvent crosses the skin's barrier and becomes systemic. Diethylene glycol monoethyl ether: DEGEE: 112-07-2: Ethanol, 2-butoxy-, acetate: Ethylene glycol monobutyl ether acetate: EGBEA: 112-34-5: Ethanol, 2-(2-butoxyethoxy)- Diethylene glycol monobutyl ether: DEGBE: a The CAS RN is the property of the American Chemical Society and any use or redistribution, except as required in supporting regulatory requirements and/or for reports to the … 10 ( 9 ):1515-21. doi: 10.3390/pharmaceutics11110607 and will become an ingredient in an increasing number prescription... Been used in cosmetic and personal care products as well as in cosmetics and personal care products well! Epoxydharze verwendet the health effects literature related to DEGEE ) is a liquid which has long... 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